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A single EBOO therapy session costs $1,500 at Purefico in Cornelius, NC. Across the United States, single sessions typically run $900 to $1,500, with budget clinics near $830 and concierge providers reaching $2,500. Because EBOO is almost always done as a course of five or more sessions, the number that actually matters is the total program cost, and that is where package pricing changes the math. EBOO is self-pay. It is not FDA-approved and is not covered by insurance.
That is the short answer. The rest of this guide explains what sits behind those numbers, because a price with no context is how people end up overpaying. We wrote this page because we wish patients had it when they first called to ask what this costs and why the range is so wide.
The honest answer is that EBOO therapy cost depends on the clinic, the location, and what is bundled into the fee. But patients don’t want a shrug; they want numbers, so here are real figures from advertised 2026 pricing across US providers.
Most single EBOO sessions land between $900 and $1,500. Below that, a few newer clinics and naturopathic offices advertise introductory or standing rates closer to $830. Above that, concierge practices in high-cost cities such as Los Angeles reach $2,500 or run new-client intros around $999, with multi-session packages priced well above that per visit.
At Purefico, a single EBOO session is $1,500. We sit deliberately in the middle of the market. We are not the cheapest option in the country, and we are comfortable telling you why, which is the subject of the next section.
Most cost pages state a price and stop. That leaves patients unable to judge whether a fee is fair. Here is what actually sits inside an EBOO session fee, so you can evaluate any clinic’s pricing, not just ours.
EBOO runs your blood through a cartridge packed with thousands of hollow fibers, the same physical design as a dialysis filter. That cartridge is used once, for one patient, then discarded. It is a genuine per-session cost that does not go away with volume.
A session runs about 45 to 60 minutes, and a licensed clinician is present throughout. That is skilled staff time you are reserving, not a drip you are left alone with.
The EBOO machine and medical ozone generator are a significant capital investment that the clinic carries and maintains. Full-spectrum systems run into the tens of thousands of dollars.
Tubing, needles, saline, and the anticoagulant that keeps blood from clotting in the circuit are all single-use and medical-grade. Cutting corners here is exactly what you do not want a clinic doing to lower a price.
Before anyone is treated at Purefico, we review your medication list, health history, and candidacy. That clinician time is built into the cost, and it is the part a cut-price operation is most likely to skip. If a provider will book you for EBOO without reviewing your history, that is your cue to leave.
A single EBOO session isn’t therapy. Most patients are advised to complete a course of at least five sessions, and the exact number depends on what you are working on. So the number that should shape your budget is not the per-session price; it is the total.
Paid one session at a time, a five-session course at the $1,500 single rate would be $7,500. That is not how we price it, because that is not how the therapy is used. Purefico package pricing runs 30 to 40 percent below the single-session rate, which brings a five-session course into roughly the $4,500 to $5,250 range, depending on the plan. We set your exact package at consultation because the right number of sessions is a clinical decision, not a sales one.
To give you an honest picture, not just our own numbers, here is how advertised EBOO pricing looks across the US market in 2026. Prices change, so treat this as a snapshot to calibrate expectations, not a live quote from any of these clinics.
| Market tier | Single session | What you often see |
|---|---|---|
| Budget / naturopathic | About $830 to $900 | Standing lower rates, fewer clinics, sometimes fewer inclusions |
| Standard / established | $1,000 to $1,500 | Where most credible clinics land; Purefico at $1,500 |
| Concierge / major city | $1,500 to $2,500 | High cost metros, premium overhead, bundled add-ons |
| Intro / promotional | $700 to $999 | First visit only, designed to bring new patients in |
No. No major US health insurer covers EBOO, and that is directly tied to its regulatory status. Under 21 CFR 801.415, the FDA classifies ozone as a toxic gas with no proven medical use in preventive or adjunctive therapy, and no ozone device holds FDA approval for therapeutic use in people. Insurers treat all ozone therapy, EBOO included, as experimental, so it is self-pay everywhere.
One practical exception is worth checking. Many clinics, including practices that accept it, find that HSA and FSA funds can sometimes be applied to EBOO because ozone therapy may qualify as an eligible medical expense. This isn’t guaranteed and depends on your plan administrator, so confirm before you assume it. We also offer payment plans, which for a multi-session course is often the more relevant question than insurance.
It is a fair question, and the honest answer is no, not on price alone, but also not on price avoidance. Cheap doesn’t automatically mean unsafe, and expensive doesn’t automatically mean better. What you are really comparing is what the fee includes.
A lower price becomes a real concern only if it comes from cutting the things that keep EBOO safe: reusing tubing or filters, using non-medical-grade ozone, or skipping the medication and history review before treatment. A higher price is only worth it if it buys genuine clinical oversight, not just a nicer waiting room. The useful questions are below.
A reasonable way to plan, without committing to anything before a consultation:
A single EBOO session typically costs $900 to $1,500 in the US. At Purefico in Cornelius, NC, a single session is $1,500, with package pricing 30 to 40 percent below that rate.
Most patients complete at least five sessions. At Purefico, a five-session course runs roughly $4,500 to $5,250 with package pricing, rather than $7,500 if you pay for one session at a time. We set your exact plan at consultation.
EBOO processes far more blood through a single-use filter over a longer session with continuous clinician oversight and more specialized equipment. Standard IV ozone treats a smaller volume without the filtration circuit, so it costs less.
No. Because ozone therapy is not FDA-approved, no major US insurer covers EBOO. It is self-pay. HSA or FSA funds may sometimes apply, depending on your plan administrator.
Not by itself. Safety comes from single-use filters and tubing, medical-grade ozone, and proper medical screening before treatment. A higher price is only worth it if it pays for genuine clinical oversight. Ask what the fee includes.
Purefico in Cornelius, NC, in the Lake Norman area about 20 miles north of uptown Charlotte, charges $1,500 for a single EBOO session, with package pricing 30 to 40 percent below that for a course.
Di Paolo N, Bocci V, Salvo DP, et al. Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. International Journal of Artificial Organs. 2005;28(10):1039-1050.
Di Paolo N, Bocci V, Garosi G, et al. Extracorporeal blood oxygenation and ozonation (EBOO) in man: preliminary report. International Journal of Artificial Organs. 2000;23:131-141.
U.S. Food and Drug Administration. 21 CFR 801.415, Maximum acceptable level of ozone.
Melissa Lynch, NP, is a nurse practitioner with 28 years of clinical experience and the founder of Purefico MedSpa & Therapy, with locations in Cornelius and Archdale, North Carolina.
