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To prepare for your first EBOO session, drink plenty of water the day before and the morning of, eat a balanced meal one to two hours beforehand, and avoid alcohol, caffeine, and high-dose antioxidants like vitamin C for 24 hours. Complete your consultation and lab work first, including the G6PD test that clears you for ozone therapy, and review all your medications with your provider. Do not fast, and wear loose sleeves so both arms are easy to access.
Those are the essentials. Below is the full picture: what to do in the week before, the day before, and the morning of, plus what actually happens during the session so nothing feels unfamiliar when you arrive. EBOO is not FDA-approved, and your own provider’s instructions always take priority over any general guide.
Good preparation makes your first session smoother, easier on your veins, and more comfortable overall. Here is what to do, broken down by when to do it.
The most important preparation happens before treatment day. Your first session should follow a consultation and any needed lab work, including the G6PD test, which checks that your red blood cells can safely handle ozone. This is also when you and your provider go through every medication and supplement you take. If anything you take affects bleeding or clotting, your provider will tell you whether to adjust it, and you should never change a prescription on your own.
Start hydrating in earnest. Steady water intake the day before genuinely changes how the session goes, because well-hydrated veins are far easier to access and blood moves more smoothly through the circuit. Skip alcohol and caffeine for the 24 hours leading up to your appointment, since both work against good hydration.
Eat a proper, balanced meal one to two hours before you arrive, something with real substance rather than a quick snack, so your blood sugar stays stable while you sit for the treatment. Keep sipping water. Wear comfortable clothing with sleeves that push up easily on both arms, since a line goes in each one. Bring a book, headphones, or anything else to keep you occupied, and give yourself extra time, because a first visit includes check-in and setup.
A few things are worth actively avoiding, and one of them surprises people.
Knowing the session format eases most first-time nerves. Here is how it actually goes, start to finish.
After a quick check on how you are feeling, you settle into a comfortable recliner, and we place two IV lines, one in each arm. The insertions feel similar to a blood draw. From there, blood is drawn from one arm, passes through the filter and the oxygen-ozone mixture, and returns through the other arm in a continuous loop. The treatment portion usually runs 45 to 60 minutes, during which most people relax, read, or rest while staff monitors how you are doing.
When it is finished, the lines come out, staff watches you briefly to make sure you feel well, and you leave with aftercare instructions. Plan a lighter day afterward, since a first visit takes a little longer overall.
The patients who have the easiest first session are almost always the ones who hydrated well and actually ate beforehand. It sounds too simple to matter, but after 28 years I can tell within the first few minutes who skipped their water that morning. Preparation is not about doing anything difficult; it is about a few small things that make the hour comfortable instead of a struggle. Come rested, fed, and hydrated, and the rest is our job.
Preparation is one part of the wider picture. If you are still deciding, it helps to understand whether EBOO therapy is safe and to check who should not have EBOO before you book. After your session, follow our EBOO aftercare guidance for the hours and days that follow, and if you want to know what your body might feel like, read about common EBOO side effects. For the full overview, start with what EBOO therapy is.
Complete your consultation and lab work first, including the G6PD test. Then hydrate well the day before and the morning of, eat a balanced meal one to two hours beforehand, avoid alcohol, caffeine, and high-dose antioxidants for 24 hours, and wear loose sleeves. Do not fast.
Yes. Eat a real, balanced meal one to two hours before your session so your blood sugar stays stable. Do not fast before EBOO, because arriving on an empty stomach makes lightheadedness more likely.
It is best to avoid caffeine for the 24 hours before your session, along with alcohol, because both work against the hydration that makes the treatment go smoothly.
G6PD deficiency means your red blood cells cannot safely handle the oxidative stress of ozone. The test, done before your first session, confirms EBOO is safe for you, which is why reputable clinics require it.
Wear loose, comfortable clothing with sleeves that push up easily on both arms, since an IV line goes in each arm. Bring something to keep you occupied for the 45 to 60 minute session.
The treatment itself runs about 45 to 60 minutes. Allow extra time for a first visit, which includes check-in, IV setup, and a short period of monitoring afterward.
At Purefico in Cornelius, NC, near Charlotte, we guide you through consultation, G6PD and lab work, and simple prep steps before your first session, then walk you through everything on the day.
Melissa Lynch, NP, is a nurse practitioner with 28 years of clinical experience and the founder of Purefico MedSpa & Therapy, with locations in Cornelius and Archdale, North Carolina.
