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EBOO vs 10-pass ozone is a common comparison because both are high-dose ozone blood therapies, but they work differently. 10-pass ozone draws a batch of blood, ozonates it, and returns it, repeating the cycle up to ten times in one session, treating roughly 2,000 ml of blood total over about 60 to 90 minutes.
EBOO runs your blood through one continuous filtered loop, treating a larger volume, up to around 4,800 ml, in about 45 to 60 minutes, and it adds a dialysis-type filter that 10-pass does not have. Neither is FDA-approved, neither is proven superior to the other, and more ozone does not automatically mean better results.
If you are choosing between them, this guide gives you the real numbers and the honest context. If you are new to ozone in general, our overview of what EBOO therapy is covers the basics first. Note that 10-pass is a higher-intensity version of standard IV ozone, so if you are comparing EBOO to basic single-pass ozone, see our separate guide on IV ozone therapy vs EBOO.
Here is an honest EBOO vs 10-pass ozone side-by-side with the real numbers. Use it to understand the differences, not as a scorecard where the bigger number wins.
10-pass ozone is an intensive form of ozone autohemotherapy. In each pass, a set amount of blood, commonly around 200 ml, is drawn, mixed with a measured oxygen-ozone dose, and returned. That cycle is repeated, often up to ten times in a single session, which is where the name comes from. Because it is done under positive pressure with a machine, more ozone dissolves into the blood than in a standard single-pass session, which is why it is described as high-dose. A full 10-pass session treats roughly 2,000 mL of blood cumulatively and takes about 60 to 90 minutes.
EBOO stands for extracorporeal blood oxygenation and ozonation. Instead of repeated batches, blood flows continuously from one arm through a machine that oxygenates and ozonates it, passes it across a dialysis-type membrane filter, and returns it to the other arm. It treats a larger total volume, up to around 4,800 mL in continuous circulation, in a shorter session of about 45 to 60 minutes.
The two defining differences from 10-pass are that EBOO is continuous rather than cyclical, and that it includes a filtration step that 10-pass does not. To understand what that filter actually does, see our guide to what EBOO filters capture.
In the EBOO vs 10-pass ozone question, this is what the comparison usually comes down to, and the honest answer is the most useful thing on this page.
EBOO treats more blood volume, and 10-pass delivers a higher cumulative ozone dose. Those are real procedural facts. What is not established is that either of those translates into better patient outcomes, or that one method beats the other. Medicine is full of examples where a more intense treatment does not produce a better result.
So separate two ideas: how much ozone or blood is processed, which is measurable, and whether that produces more benefit, which neither method has proven. Choosing by intensity alone is choosing on the wrong basis.
You will see some pages claim EBOO’s filter “cleans your blood of heavy metals, fungi, and bacteria,” and use that to position EBOO as clearly superior to 10-pass. Be cautious with that. The filter can physically trap some larger circulating debris, but it does not reliably remove heavy metals, which are far smaller than its cutoff, and it is not a proven way to clear infections from the blood.
The filtration step is a genuine difference between EBOO and 10-pass, but it should be described accurately, not oversold. For the full details, our EBOO therapy myths article covers it.
Cost usually differs between the two. 10-pass ozone commonly runs around $750 to $900 per session, while EBOO tends to run higher, roughly $900 to $1,500, reflecting the larger volume, the filter, and the equipment. Neither is covered by insurance, since neither is FDA-approved. Both are typically done as a series rather than a single visit, so ask any provider for the total cost of a recommended course, not just one session. For the fuller picture on pricing, see our guide to what EBOO therapy costs.
When it comes to EBOO vs 10-pass ozone, the right choice depends on your goals, your budget, and a provider’s assessment, not on which sounds more advanced.
10-pass may suit you if you want high-dose ozone without the filtration step, it costs less, or a provider recommends it for your situation. EBOO may suit you if you specifically want the continuous, filtered, higher-volume approach and accept the higher cost.
Both require proper screening, including for G6PD deficiency, and some people are not candidates for either, so it is worth reading whether EBOO therapy is safe and who should not have EBOO before you decide. The honest bottom line is that this is an individual decision made with a provider, not a contest where the higher-volume option automatically wins.
Patients often come in having already decided they want the “strongest” option, and part of my job is to gently reframe the EBOO vs 10-pass ozone question. They are different tools, not a ranking. For one person, the cyclical high-dose approach is the right fit; for another, the continuous filtered method makes more sense; for many, either would be reasonable. I would rather match you to what suits your goals and budget than upsell you to whichever processes the most blood. Intensity is not the same as benefit, and I will always tell you that plainly.
The core difference between EBOO and 10-pass ozone: 10-pass cycles a batch of blood up to ten times, treating about 2,000 ml total with no filter, while EBOO runs blood through one continuous loop, treating a larger volume (up to about 4,800 ml) and adding a dialysis-type filter. EBOO is continuous and filtered; 10-pass is cyclical and unfiltered.
Not necessarily. EBOO treats more blood volume and adds filtration, but more volume and more ozone are not proven to produce better outcomes, and neither method is established as superior to the other. The right choice depends on your goals, budget, and provider assessment.
A 10-pass session treats roughly 2,000 ml of blood cumulatively, about 200 ml per pass over ten passes. EBOO treats a larger volume in continuous circulation, up to around 4,800 ml in a session.
EBOO usually costs more, roughly 900 to 1,500 dollars per session, versus about 750 to 900 dollars for 10-pass. The difference reflects EBOO’s larger volume, filter, and equipment. Neither is covered by insurance.
No. The EBOO filter does not reliably remove heavy metals; metal ions are far smaller than its cutoff. Claims that the EBOO filter removes heavy metals, fungi, or bacteria are overstated. The filter is a real difference from 10-pass, but it should not be described as a heavy-metal detox.
At Purefico Medspa and Longevity Center in Cornelius, near Charlotte, we choose between EBOO, 10-pass, and other ozone methods at a consultation based on your goals, budget, and health history, with honest guidance on what each can and cannot do.
1. Di Paolo N, Bocci V, Salvo DP, et al. Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. International Journal of Artificial Organs. 2005;28(10):1039-1050. (EBOO can treat up to 4,800 mL of heparinized blood in about one hour.)
2. Technical report on countercurrent membrane ozone systems (“ozone dialysis”), 2022. (Higher ozone uptake with countercurrent design; technical, not clinical proof.)
3. Bocci V. OZONE: A new medical drug. Dordrecht: Springer; 2011. (Autohemotherapy dosing and ozone pharmacodynamics.)
4. U.S. Food and Drug Administration. 21 CFR 801.415, Maximum acceptable level of ozone.
Melissa Lynch, NP, is a nurse practitioner with 28 years of clinical experience and the founder of Purefico MedSpa & Therapy, with locations in Cornelius and Archdale, North Carolina.
